Polypharmacology of dopamine D1-like receptor antagonists
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چکیده
منابع مشابه
Polypharmacology of dopamine D1-like receptor antagonists
Drug discovery based on development of selective ligands for a specific target intended to modulate its activity and revert pathophysiological process is now recognized as too simplistic to design effective agent for complex multifactorial diseases, characterized by diverse physiological dysfunctions caused by deregulations of complex networks of proteins. Major challenge in modern drug discove...
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In this study, the influence of dopamine receptor agonists and antagonists on antinociception induced by bac10fen has been examined in the formalin test. The GABA-B agonist bac10fen induced antinociception in both phases of the formalin test in mice. The dopamine receptor agonists SKF 38393 and quinpirole also induced antinociception in both phases of the test. SKF 38393 but not quinpirole ...
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ژورنال
عنوان ژورنال: Arhiv za farmaciju
سال: 2015
ISSN: 0004-1963
DOI: 10.5937/arhfarm1505287n